No. Levels of hormones are normal in people with PMDD, but they have an abnormal mood reaction to normal hormone changes that occur across the menstrual cycle. When we use experimental methods to manipulate hormones in females with and without PMDD, we see that only people with prospectively-confirmed mood symptoms show a negative reaction to the hormone manipulation (Schmidt 1998), but that this goes away after a little while (probably about a month; Schmidt 2017).

Updated 22 December, 2018 by Tory Eisenlohr-Moul, PhD

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