PME, or premenstrual exacerbation of an underlying disorder, occurs when a woman has a chronic diagnosis (e.g., depression, anxiety, arthritis) that is made worse prior to and potentially during her period. The symptoms follow a similar trajectory to PMDD, but they never resolve completely. So far, it looks like we might need different treatments for symptoms that follow the PMDD vs PME patterns, since the latter don’t seem to respond to our PMDD treatments (Lupron, Sepranolone) very well. We need more research on the causes of both.
Updated 22 December, 2018 by Tory Eisenlohr-Moul, PhD