MTHFR (methylenetetrahydrofolate reductase) deficiency is a heritable genetic mutation that has been found to contribute to the worsening mood symptoms in conditions like depression and anxiety. Because of the high prevalence of MTHFR deficiency in people with mood disorders, it is reasonable to be tested for this deficiency, especially if you are not responding to your current PMDD treatment regimen. Treating the underlying MTHFR deficiency might help alleviate some of the symptoms of PMDD. Talk to your doctor about treatment options that might be appropriate for you.
-Gioia Guerrieri, DO, February 25, 2019