What “underlying disorders” can show premenstrual exacerbation (PME)?

The short answer is, probably all of them.

The long answer is that It has been demonstrated that many different psychiatriatric disorders can worsen significantly prior to and during menstruation. Not all women/AFAB individuals with psychiatric disorders are sensitive to hormone changes; therefore,some women/AFAB individuals with underlying disorders show worsened symptoms before or during their periods (PME), and some do not.

We know, however, that PME is a widespread problem, as it has been observed to be common in a variety of populations, including (but not limited to) females/AFAB with depressive disorders, post-traumatic stress disorder, eating disorders, substance abuse disorders, borderline personality disorder, and those with chronic suicidality.

Research on this topic is rapidly progressing, and each year we learn about another disorder that can be complicated or worsened among women/AFAB who are sensitive to hormone changes.