Since estrogen serves to protect cognitive function (thinking, memory) as we age, early oophorectomy (surgical menopause) is associated with poorer cognitive function over time, and can increase the risk of serious cognitive problems (i.e., dementia) and associated risky biological changes in the brain. 

There is also evidence that these risks are greater the earlier one starts surgical menopause. However, as with many surgical menopause risks, this risk seems to be minimized or eliminated by estrogen HRT. 

​Visit www.iapmd.org/surgery for lots of evidence based information and resources for those considering, going through or recovering from surgery for PMDD/PME.