This will vary from patient to patient. While for some patients the treatment works quickly (about 2 weeks) for others it will take 2 /3 months for the GnRHa agonists to suppress the menstrual cycle.

In these first weeks, it is common to have a ‘flare’ in hormone levels, and therefore you may experience PMDD - like symptoms, as your brain adjusts and downregulates its hormonal stimulation to your ovaries.