There is some support for Spironolactone’s use in managing the physical PMDD symptoms that some people experience.
A double-blind, placebo-controlled, crossover study assessing the administration of spironolactone 100 mg/day during the luteal phase found a significant decrease in several PMDD symptoms, such as:
swelling
breast tenderness
food cravings
Speak to your provider if this is a treatment you are considering.
Dr. Jaclyn Ross, Ph.D. - Licensed Clinical Psychologist
Added June 2023