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Do those with PMDD have issues metabolizing hormones such as progesterone or estrogen in the liver? Is this a clearance issue or an accumulation issue? What helps if this is the case?
Do those with PMDD have issues metabolizing hormones such as progesterone or estrogen in the liver? Is this a clearance issue or an accumulation issue? What helps if this is the case?

Liver. Metabolise. Blood tests.

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Written by IAPMD
Updated over a year ago

No, there is no evidence that those with PMDD have issues metabolizing estrogen or progesterone. If this were the case, research would show that individuals with PMDD have higher levels of estrogen or progesterone in the blood.

Many studies have tested this and have not found differences in blood levels of these hormones between patients with PMDD and controls.

Updated 31 May 2023

Jordan C. Barone

IAPMD CAB Affiliate

MD/Ph.D. Candidate (Medical Scientist Training Program)

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