No, there is no evidence that those with PMDD have issues metabolizing estrogen or progesterone. If this were the case, research would show that individuals with PMDD have higher levels of estrogen or progesterone in the blood.
Many studies have tested this and have not found differences in blood levels of these hormones between patients with PMDD and controls.
Updated 31 May 2023
Jordan C. Barone
IAPMD CAB Affiliate
MD/Ph.D. Candidate (Medical Scientist Training Program)